Journal: Frontiers in Computational Neuroscience
Article Title: ROOTS: An Algorithm to Generate Biologically Realistic Cortical Axons and an Application to Electroceutical Modeling
doi: 10.3389/fncom.2020.00013
Figure Lengend Snippet: (Top) Dorsal aspect of the enclosed blade (suprapyramidal) portion of an entorhinal cortical axon generated by one of two methods: Trees Matlab toolbox (BF = 5), and the proposed algorithm. Balancing factor, and connection threshold for the Trees toolbox were selected to align these distributions aligned favorably. (Bottom) Fundamental statistical distributions comparing the two methods in terms of nodal path length, direct distance vs. path distance, branching order, branch lengths, and bifurcation angles. The plotted curves represent probability densities and the box represents the mean. Despite matching many features of the proposed algorithm, the Trees generated arbor does not capture the en passant nature of the perforant path [seen in branching order (A), and length (B)] and has lingering bifurcations which have extreme angles (C).
Article Snippet: To test the functionality of this algorithm in comparison with others that already exist, we attempted to create satisfactory arbors with two commonly used alternative tools which were originally designed to grow dendritic arbors: the TREES Matlab toolbox , and L-NEURON ( ; ).
Techniques: Generated